COVID-19andmycoplasmapneumoniaecoinfection

BingwenEugeneFan,KianGuanEricLim,VanessaCuiLianChong,StephreneSeokWeiChan,KiatHoeOng,PonnuduraiKuperan

A36-year-oldChinesemanwitharecentdiagnosisofCOVID-19infectionwastreatedintheNationalCentreforInfectiousDiseases,Singapore.Hewasfoundtohavesevere[严重的]lymphopenia[淋巴细胞减少]andmoderate[中等的]thrombocytopenia[血小板减少]onadmissiontoICUandrequiredventilator[呼吸机]support.Peripheralbloodsmearperformedinviewof[鉴于]arisingMCVfrom86fLto92fLdemonstratedcoldagglutination[冷凝集]androuleaux[缗钱状]formation,lymphopeniawithfewreactivelymphocytesandrarelymphoplasmacytoid[浆样淋巴]cells(Image1A,B,Wrightstain,×objective).Therewasnosignificantanemia[贫血]orbiochemicalhaemolysis[溶血]anddirectagglutinationtestwasnegative.Antibodyscreen[筛查]revealedanti-Iantibody,acoldagglutinin[凝集素]titer[滴度]of1:8withamycoplasma[支原体]pneumoniae[肺炎]antibodytiterof1:.Serumelectrophoresis[电泳]didnotshowamonoclonal[单克隆的]antibody.Respiratorymultiplex[多通路]PCRforother